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New research links the use of high doses of anabolic steroids to tendon and collagen dysfunction, which may make a bodybuilder think twice about training heavily while using anabolics, a new report says.The study, published online in the New England Journal of Medicine, looked closely at the use of anabolic steroids among nearly 5,000 amateur weight lifters throughout the United States beginning in 1993 and concluded that they cause tendon stress and collagen inflammation similar in nature to conditions associated with previous use of the drugs."The results of our study indicate that the acute use of steroids can lead to severe tendon injuries, which can be fatal," James G. Miller, M.D., chief of Division of Bone and Joint Surgery at the Mayo Clinic in Rochester, Minnesota, and a member of the study team, said in a statement.Miller said that the use of steroids and body mass -- a physical characteristic that refers to weight, weight class and length of time a person is measured -- is linked to an increase in tendon conditions, including tendon and collagen stress."Tendons are the connective and connective tissue of bones and muscles," he added. "Tendon injuries include both acute and chronic symptoms."Miller said the current study looked at both the acute use of steroids and body weight for three years before the participants were followed up. However, he noted that this was a retrospective study, not a prospective inquiry. And in retrospect, the research was limited because only six percent of the participants were used to steroids during the study.The study looked at the percentage of the study participants using steroids before and after the use of any of the four anabolic steroids in the study. When all the tests were done, the authors found that among the study participants who used steroids before 1993, more than half (59 percent) had tendon pain and an increase in collagen damage, compared with less than half (42 percent) who used anabolic steroids in the study after 1993. In the remaining cases, there was more variability because the use of steroids is not uniform across ages and genders, which makes it hard to draw clear conclusions. The study did not look at how steroid use affects the incidence of tendon injuries, which can be severe and life-threatening."While a number of studies have shown that some of these tendon injuries are more severe than others, the findings above suggest that, on average, more than half of the tendon tissues in the study had increased tendon stress," Miller said.Similar articles: